Manafwa District is located in the Eastern Region of Uganda, bordering the Republic of Kenya in the East; District of Bududa in the North; Mbale to the West and Tororo in the Southwest. It lies between the longitudes of 340 E, 350E and latitudes 000450N The District has a land area of about 451sq km.

Manafwa District can be divided into three distinct topographical regions, namely lowland Manafwa; Upland Manafwa and the mountain landscapes. On average the plain run in the west-south direction, from the borders of Mbale District to the south through to Tororo District. The dominant altitude of this landscape is slightly over 1800m, but with many features higher.